Haematological Characteristics of Myeloid Acute Leukaemia in Tunisia

The purpose of this study is a bio-clinical review according to the WHO recommendations in 153 cases of LAM. The patients were aged 2 months to 90 years with sex ratio (M/F) of 1,22. The morphologic conclusion was difficult in 12% cases. Presence of dysplasia is noted in 50% of cases with multilineage dysplasia in 42% of cases. Our results showed cloned chromosomal abnormalities in. 57% of cases( t(8;21): 12%, t(15 ;17): 10%, Inv16: 1,3%, 11q23 :2,6% et complex karyotype:14,3%). In 69% of cases with avec multilineage dysplasia, the karyotype was normal. 3 cases of LAM were noted at patients treated for breast cancer with chirurgic chemotherapy and radiotherapy 3, 4 et 5 years after treatment (LAM3 with t(15;17), LAM4 with genetic abnormalities of chromosomes3,5,7,8,9,14 et 16 et LAM 6 with genetic abnormalities of chromosomes4,7,12,14,19 et 21). In WHO classification, cytology is essential in diagnosis of LAM even if the karytype have an important prognostic value. Research of signs of dysplasia lineage after lineage constitutes an important microscopic work and it is difficult to quantify dysplasia when the lineage is poor.